NPTEL Organ Printing Week 5 Assignment Answers

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NPTEL Organ Printing Week 5 Assignment Solutions

NPTEL Organ Printing Assignment Answers 2023

NPTEL Organ Printing Week 5 Assignment Answers 2023

1. In the context of bioprinting vasculature, what is the primary challenge associated with ensuring proper nutrient exchange and waste removal within the printed vascular network?

  • Regulating blood pressure within the vessels
  • Achieving precise alignment of vascular channels
  • Controlling endothelial cell differentiation
  • Establishing functional capillary beds
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2. What are the critical functions of the bioink in bioprinting vasculature, and how do these functions contribute to the formation of functional blood vessels?

  • Bioink facilitates oxygen transport only; other functions are secondary
  • Bioink supports cell attachment but has minimal impact on vessel formation
  • Bioink provides mechanical support, guides cell behavior, and promotes angiogenesis
  • Bioink accelerates blood flow within the vessels but does not influence vessel structure
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3. Discuss the advantages and limitations of direct printing of vasculature. How does this approach address challenges related to vessel size, cell types, and network complexity in bioprinting?

  • Direct printing is limited to large vessels; small vessels are not achievable
  • Direct printing offers precise control over vessel size and cell composition; network complexity is unattainable
  • Direct printing is suitable for complex networks; cell viability is compromised
  • Direct printing lacks control over vessel size and network complexity; it excels in cell viability
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4. Explain the concept of sacrificial bioinks in the indirect bioprinting of vasculature. How do sacrificial bioinks facilitate the formation of intricate vascular networks and their subsequent removal?

  • Sacrificial bioinks are irrelevant in vasculature bioprinting; they hinder network formation
  • Sacrificial bioinks promote vascular network degradation; they hinder vessel stability
  • Sacrificial bioinks serve as temporary templates for vessel formation; they are subsequently removed
  • Sacrificial bioinks enhance cell attachment to vessel walls; they remain in the construct
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5. In the design of a tissue-mimetic bioink for cornea bioprinting, what other tissue-like properties should the bioink possess to mimic a corneal equivalent?

  • Bioink must mimic the properties of bone tissue; it has minimal impact on cornea functionality
  • Bioink should replicate the stiffness of cartilage; it enhances cornea stability
  • Bioink needs to resemble the mechanical properties of lung tissue; it supports cell behavior and tissue integration
  • Bioink should have the consistency of adipose tissue; it accelerates cornea regeneration
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6. Based on the level of complexity for vasculature for bioprinting the organs can be arranged (Low to High).

  • Skin>Trachea>Bladder>Kidney
  • Skin>Bladder >Trachea >Kidney
  • Kidney>Skin>Trachea>Bladder
  • Skin> Bladder>Trachea>Kidney
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7. What are the different layers of bigger blood vessels-

  • Tunica Intima, Tunica Media, Tunica Adventitia
  • Tunica Maxima, Tunica Media, Tunica Adventitia
  • Tunica Minima, Tunica Media, Tunica Adventitia
  • None of the above
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8. Which one has very high fidelity-

  • Direct 3D printing of blood vessels
  • Indirect 3D printing of blood vessels
  • All of the above
  • None of the above
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9. The cornea tissue has a total no. layer-

  • 4
  • 5
  • 3
  • 6
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10. Corneal transparency mainly depends on-

  • Cellular organization
  • Orthogonal arrangement of collagen fibrils
  • Matrix composition
  • None of the above
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11. Biomimicry can be suited for corneal bioprinting to replicate the-

  • Orthogonal arrangement
  • Maintaining layers of cornea
  • Maintaining composition
  • All of the above
  • None of the above
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12. The major resident cells of corneal stroma are-

  • Smooth Muscle cells
  • Keratocytes
  • Epithelial cells
  • All of the above
  • None of the above
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13. The major function of Endothelial cells is-

  • Cellular differentiation
  • Autonomous self-assembly
  • Maintaining osmotic balance
  • All of the above
  • None of the above
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14. Bioprinting technology should be capable of mimicking the vascular tress by:

  • Direct 3D printing
  • Indirect 3D printing
  • 3D printing in support bath
  • All of the above
  • None of the above
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15. Compare the challenges and advantages of 3D bioprinting the cornea using single material bioinks versus multimaterial bioink systems. How does each approach influence the ability to replicate the intricate corneal microstructure and promote tissue function?

  • Single-material bioinks hinder cornea microstructure replication; multimaterial systems support better tissue functionality
  • Both single-material and multimaterial bioinks offer similar advantages in cornea bioprinting
  • Single-material bioinks support better microstructure replication; multimaterial systems excel in promoting tissue functionality
  • Neither single-material nor multimaterial bioinks are suitable for cornea bioprinting
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Course NameOrgan Printing
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