NPTEL Organ Printing Week 4 Assignment Answers 2023

NPTEL Organ Printing Week 4 Assignment Solutions

NPTEL Organ Printing Week 4 Assignment Answers 2023

1. Which design approach, “bottom-up” or “top-down,” is more suitable for achieving intricate tissue microarchitecture, and how does this choice influence the potential for cellular interactions and functional integration?

1. Bottom-up approach is suitable; it enables precise microarchitecture and encourages cellular interactions
2. Top-down approach is preferable; it allows better control over cellular interactions and integration
3. Both approaches are equally effective in achieving intricate microarchitecture and cellular interactions
4. Neither approach supports intricate microarchitecture or cellular interactions effectively

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2. Arrange the following organs based on the level of complexity (Low to High)-

1. Skin > Trachea > Bladder > Kidney
2. Skin > Bladder > Trachea > Kidney
3. Kidney > Skin > Trachea > Bladder
4. Skin > Bladder > Trachea > Kidney

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3. What is the major challenge with bioinks for bioprinting?

1. Rheology
2. Cell Viability
3. Printability
4. All of the above
5. None of the above

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4. What role does the “shear-thinning behavior” of a bioink play in the context of extrusion bioprinting?

1. It promotes rapid bioink degradation for quicker printing
2. It ensures uniform bioink viscosity throughout the printing process
3. It enables controlled flow during extrusion, allowing precise deposition
4. It enhances cell adhesion to the substrate after printing

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5. The printing fidelity is very good with –

1. Low viscous bioink
2. Moderate viscous bioink
3. High viscous bioink
4. All of the above

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6. Which parameter of the printing process significantly affects the “aspect ratio” of bioprinted structures, and how does it impact the construct’s mechanical stability?

1. Bioink composition; higher aspect ratio enhances stability
2. Nozzle diameter; higher aspect ratio decreases mechanical stability
3. Extrusion speed; aspect ratio has minimal impact on stability
4. Layer height; higher aspect ratio compromises mechanical stability

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7. Nutrient diffusion without complete vascularization would not be a major issue for the following organ –

1. Kidney
2. Skin
3. Liver
4. Pancreas
5. Self-assembly of bioactive factors
6. None of the above

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8. Requirements for direct 3D bioprinting of organs:

1. Tissue-specific bioink (bioactive as well)
2. Tissue-mimicking nano to micro architecture
3. Different cell types and extracellular matrix
4. Patterning of living cells into hydrogel tissue scaffolds
5. All of the above

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9. ECM is related to –

1. Acellular components present in the tissues
2. Components present within the cells
3. Synthetic biomaterial component
4. None of the above

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10. Among the following, which is a crucial challenge in bioprinting vascularized organs, and how does it affect the viability of the printed tissue?

1. Achieving cell differentiation; it hinders vascularization
2. Designing a functional vascular network; inadequate perfusion limits tissue viability
3. Selecting a suitable scaffold; it increases vascularization efficiency
4. Employing lower resolution bioprinters; it enhances vascularization complexity

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11. “Scaffold-free’ version deals with

1. Self-assembling of cellular spheroids that undergo fusion and cellular organization to mimic developing tissues
2. Self-assembling of mini tissues that undergo fusion and help in developing tissues
3. Self-assembling of biomaterials scaffolds that undergo fusion and develop tissues
4. All of the above
5. None of the above

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12. Self-assembly of vascular building blocks to form branched vascular networks is an example of –

1. Biomimicry
2. Autonomous self-assembly
3. Mini-tissues
4. None of the above
5. All of the above

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13. In the context of bioprinting, which statement accurately reflects the complexity of replicating tissue microarchitecture and cellular heterogeneity?

1. Tissues have simpler microarchitecture, but higher cellular heterogeneity compared to whole organs
2. Tissues and whole organs have comparable complexity in both microarchitecture and cellular heterogeneity
3. Tissues possess higher microarchitectural complexity but lower cellular heterogeneity than whole organs
4. Both tissues and whole organs exhibit similar complexity, with microarchitecture and cellular heterogeneity posing unique challenges

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14. What distinguishes “scaffold-based” from “scaffold-free” design approaches in bioprinting, and how does each approach impact the cellular environment and construct stability?

1. Scaffold-based approach uses natural materials only; scaffold-free approach provides mechanical support
2. Scaffold-based involves incorporating synthetic polymers; scaffold-free relies solely on cellular interactions
3. Scaffold-based uses a cell-free framework; scaffold-free relies on cell-cell interactions for mechanical stability
4. Scaffold-based offers mechanical support with materials; scaffold-free relies on cellular interactions for stability

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15. Fabrication time can be enhanced without compromising resolution with the following bioink –

1. High viscous
2. Low viscous
3. Moderate viscous
4. All of the above
5. None of the above

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Course Name	Organ Printing
Category	NPTEL Assignment Answer
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